This one is pretty critical release. We have been waiting for this a long time and it is now out there and available. Thanks to David, Mariano & Janakiram to inform us in the first place.
Follow this CustomerSource link and you would be getting it right on your GP environment: Microsoft Dynamics GP 10.0 SP4 CustomerSource Link. Follow this MSFT Dynamics GP Official Blog Link to make use of several important links leading to critical information.
But also make sure that you follow the instructions before just installing it on any Production Environment.