There won’t be any performance issues obviously as stated by him, but there are some crucial points that we need to think about before enabling it.
Enabling it on live environment is like inviting disaster. I remember I used to do that, but only after all users log off from GP. That particular customer, they don’t work 24/7 which gave me the confidence to enable it on live and disable it back once my troubleshooting was over. I would have been in very deep trouble easily had I not remembered disabling that after my task.
Even a single Dex debug message box would be more than enough to drive a user crazy.